BEPO is composed of diblock (DB) and triblock (TB) copolymers containing hydrophilic and water-soluble blocks (PEG – polyethylene glycol) linked with hydrophobic and amorphous blocks (PLA – Poly(D,L-lactic acid)), which form a semi-solid depot when exposed to an aqueous environment. The hydrophilic blocks can interact with hydrophilic APIs and permit for their controlled release, whereas the hydrophobic blocks are able to solubilise and retain hydrophobic APIs. BEPO copolymers Molecular Weight (MW) range from 3 to 35 kDa.
BEPO also contain solvent and selected Active Pharmaceutical Ingredients (API). Its physicochemical properties make it an ideal vehicle for a wide range of APIs such as sensitive peptides, proteins, antibodies and small molecules.
PEG (polyethylene glycol) block
Also known as polyethylene oxide (PEO)
Commercially available over a wide range of MW (0.3 to 10 000 kDa)
Hydrophilic, water soluble
Poly(D,L-lactic acid) or poly(D,L-lactide)
Prepared by polymerization (ROP) of cyclic (D,L)-lactide monomer
Biodegradable macromolecule (through hydrolysis)