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MedinCell has launched a COVID-19 research initiative based on its experience to formulate long-acting injectable Ivermectin

April 6, 2020

First in-vitro validation of impact of Ivermectin on Covid-19 by Australian researchers

• Researchers at Monash University in Melbourne, Australia, have published last Friday a study showing that antiparasitic drug Ivermectin can kill coronavirus in a laboratory setting in under 48 hours. A single treatment is able to effect ∼5000-fold reduction in virus at 48h in cell culture1.
• Ivermectin has a long track record of use as a safe and effective drug to treat several parasitic diseases.
• MedinCell has published data showing that long-acting formulations of Ivermectin can be designed with varying doses and durations with its BEPO® technology2 and is already leading a program aiming at developing a 3-Month injectable product to fight malaria3.
• MedinCell has launched a few weeks ago a research initiative on a long-acting injectable formulation of Ivermectin and believes it could have a role to play in Covid-19 management.
• Future clinical studies will have to confirm the action of Ivermectin on Covid-19 virus, and the potential effectiveness of a long-acting injectable on its prevention and therefore breaking the chain of transmission.
• In case of positive results, a BEPO® technology based long-acting injectable Ivermectin offers a rapidly deployable and affordable solution for a global pandemic.

1 The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro – Leon Caly, Julian D. Druce, Mike G. Catton, David A. Jans,
Kylie M. Wagstaff – Antiviral Research, 3 April 2020
2 Source: BEPO®: Bioresorbable diblock mPEG-PDLLA and triblock PDLLA-PEG-PDLLA based in situ forming depots with flexible drug delivery
kinetics modulation – Christophe Roberge, Jean-Manuel Cros, Juliette Serindoux, Marie-Emérentienne Cagnon, Rémi Samuel, Tjasa Vrlinic,
Pierre Berto, Anthony Rech, Joël Richard, Adolfo Lopez-Noriega – Journal of Controlled Release, Volume 319, 10 March 2020, Pages 416-427
3 Company press release: MedinCell receives $ 6.4 million grant from Unitaid to fight Malaria – 03.25.2020

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