The licence agreement complements the collaboration between Medincell and the health agency Unitaid that funds the development of mdc-STM, an investigational long-acting injectable formulation for the prevention of malaria.
The Medicines Patent Pool (MPP) is a United Nations-backed public health organisation working to increase access to, and facilitate the development of life-saving medicines for low- and middle-income countries.
The licence agreement relates to a 3-Month active injectable formulation of ivermectin using Medincell’s BEPO® technology to fight malaria transmission.
The licence agreement aims to ensure that the product be widely distributed in low- and middle-income countries if proven effective and safe.
Malaria remains endemic in 91 countries leading to 627,000 deaths in 2020. Children under 5 are the most vulnerable, accounting for 80% of deaths.
Geneva (Switzeland) and Jacou (France) – The Medicines Patent Pool (MPP) and French pharmaceutical company MedinCell today announced that they have signed a licence agreement for a candidate long-acting drug formulation that could be used to fight malaria in low- and middle-income countries.
This non-exclusive licence agreement, made possible with funding to both parties from global health agency Unitaid, will enable MPP to support the identification of suitable partners for the development and commercialisation of mdc-STM, an injectable formulation of ivermectin with a three-month action-duration, using MedinCell’s BEPO® technology. Under the terms of the licence, the manufacturing can be carried out in any country worldwide, for distribution in low- and middle-income countries.
Now at a pre-clinical stage, the product is based on BEPO®, a MedinCell polymer-based injectable technology that enables the sustained release of ivermectin after a single injection administered subcutaneously at the beginning of the malaria transmission season to people living in malaria-endemic areas. Mosquitoes feeding on persons having received ivermectin injections will be killed or made less capable of transmitting malaria parasites further. Through this community-based intervention – the individual receiving the injection will not be protected against malaria directly – the number of mosquitoes will be decreased, thus benefiting the whole community by lowering the risk of transmission of malaria, particularly in children.
If proven safe, effective and acceptable, this long-acting injectable candidate could have a significant impact on transmission of malaria among vulnerable populations in high-transmission areas, in particular young children who are adversely affected.
“We are very proud to be partnering with MedinCell to accelerate the development of such paradigm-changing interventions and ensure these innovations, if proven safe and effective, are available in low- and middle-income countries as soon as possible” said Charles Gore, Executive Director of MPP.
“This long-acting technology offers an exciting new avenue in the fight against malaria, and this licence is key to allow rapid access to innovation for those who need it most.
Malaria remains endemic in 91 countries representing 50% of the world’s population. According to WHO estimates, 241 million people were infected worldwide in 2020, 95% of them in Africa, leading to 627,000 deaths. Children under 5 are the most vulnerable, accounting for 80% of deaths from malaria.
“Collaboration and innovation are key to face major Global Health challenges, said Christophe Douat, CEO of MedinCell. Bringing together the best players to move this project forward is crucial to ensure that this innovative product based on our long-acting Injectable technology, if proven safe and effective, can have a positive impact for affected population. We are delighted to join forces with MPP which could play an essential role in enabling rapid and global access to this new complementary tool to fight the malaria scourge.”
This successful early-stage collaboration is part of Unitaid’s larger strategy to accelerate the development of affordable, quality, long-acting products for infectious diseases. As part of that work, Unitaid is funding both MedinCell to develop long-acting antimalarial products and MPP to facilitate generic production of the new technologies without delay. “In the fight against malaria, there is no time to lose. We know that, if proven safe and effective, this long-acting malaria prevention will hold tremendous potential. By supporting development and access pathways simultaneously, Unitaid is investing on all fronts to fast-track access to new malaria fighting tools,” said Dr Philippe Duneton, Executive Director of Unitaid.
The licence agreement covers all low- and middle-income countries and is royalty free in the public sector, with reasonable royalty in line with industry standards to be agreed in case there would be a private market for the licensed product in low and middle- income countries.
Access the licence agreement