Internship: Development of innovative polymer-based formulations

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The BEPO® technology was developed by MEDINCELL in order to assure controlled and sustained delivery of active ingredients over a pro-longed period (from few weeks up to several months). The technology is based on the formulation of three main components: a mixture of biodegradable copolymers, an Active Pharmaceutical Ingredient (API) and a biocompatible solvent. The liquid formulation once injected in the subcutaneous tissue will quickly precipitate and form a solid depot, with the API entrapped in the copolymer matrix. This in-situ forming implant will act as an API reservoir which will gradually release the desired quantity of active ingredient over the time. Even though the technology is very versatile, there are still some limitations encountered, such as for example, a formulation of APIs with atypical Physico-chemical properties and/or utilization of technology for alternative routes of administration.

Internship Mission:

  • You will be in charge of the design and evaluation of new formulations able to surpass these limits.
  • Research and test new polymers with different features and excipients in order to obtain semi-solid depots with desired physiochemical and mechanical properties. In particularly, the influence of polymer type and API type on the phase exchange, depot formation, API release kinetics and polymer degradation will be examined.
  • Performing Analytical (HPLC, FTIR, SEM, SEC) and imaging (Ultrasound, X-ray microtomography) characterization methods.
  •  Data analysis and interpretation of the results

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