THIS IS BEPO®
FOR A NEW GENERATION
A GAME-CHANGING DELIVERY SYSTEM FOR LONG-ACTING INJECTABLES
BEPO® is a simple yet flexible technology. Based on our custom proprietary copolymers and a biocompatible solvent (where the API is solubilized or suspended), BEPO® forms a fully bioresorbable depot once injected.
The BEPO® technology makes it possible to control and guarantee the regular delivery of a drug at the optimal therapeutic dose for several days, weeks or months starting from the subcutaneous or local injection of a simple deposit of a few millimeters, fully bioresorbable
BEPO® can be administered subcutaneously for systemic exposure of APIs or locally for targeted treatments.
How it works
BEPO® is composed of a solution of diblock (DB) and triblock (TB) copolymers containing hydrophilic and water-soluble blocks (polyethylene glycol – PEG) linked with hydrophobic and amorphous blocks (Poly(D,L-lactic acid) – PLA) which precipitate in forming a depot when exposed to an aqueous environment. The API is entrapped within the polymer matrix and is released thereafter by difusion and following polymer degradation. The hygroscopy and consequently the API release kinetics from the depots can be fine tuned by adjusting the hydrophilicity of the DB and TB and their relative ratio.
PEG (polyethylene glycol) block
• Also known as polyethylene oxide (PEO)
• Commercially available over a wide range of MW
• Hydrophilic, water soluble
• PLA block
• Poly (D,L-lactic acid) or poly (D,L-lactide)
• Prepared by polymerization (ROP) of cyclic (D,L)-lactide monomer
• Amorphous, hydrophobic
• Biodegradable macromolecule (through hydrolysis)
A FLEXIBLE TECHNOLOGY
The possibility of fine-tuning all of BEPO’s® components gives us the opportunity to truly tailor products, able to fit the therapeutic needs of the patient.
We’re always looking for new talent
The people of MedinCell aren’t just creating life-sustaining products, their aim is to revolutionize the patient’s way of life. Interested in being part of an employee owned, creative workplace?